Hydrochloric Acid → Ethanolamine

HRID 362307Notes

Reaction equation

HRID 362307 reaction equation
[C:1]1([C:7]2[C:15]3[C:14]([NH2:16])=[N:13][CH:12]=[N:11][C:10]=3[N:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][CH2:25][NH:26]CCO)[CH:18]=3)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:30]>>[C:1]1([C:7]2[C:15]3[C:14]([NH2:16])=[N:13][CH:12]=[N:11][C:10]=3[N:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH2:24][CH2:25][Cl:30])[CH:18]=3)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:26][CH2:25][CH2:24][OH:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53682953HCID 53682953, compound

Product 2

HCID 700EthanolamineHCID 54189542HCID 54189542, compound

Procedure

5-Phenyl-7-[3-(2-(2-hydroxyethylamino)ethoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine, m.p. 188°-189° C., or a salt thereof, e.g. the hydrochloride. The free compound is obtained by reaction of 5-phenyl-7-[3-(2-chloroethoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine (see Example 108) and 2-aminoethanol.

Sources & evidence

ORD record
ord-da0ec8b8706240b5a848cd0bef1c4439
Source dataset
uspto-grants-1999_02
Patent number
US05869485

Reaction notes

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