反应详情

The alkylation of 5-cyclopropyl-2,4-dihydro-2-(2-nitrophenyl)-3H-1,2,4-triazol-3-one with 5-[4'-bromomethyl)biphenyl-2-yl]-N-trityltetrazole (see Example 2, Step B) was carried out as described in Example 4, Step D, except that a 20% excess of sodium hydride and 20% excess of the alkylating agent were used. After work-up, the crude product mixture was flash chromatographed on silica gel (124 mL for 0.467 mmole, eluted with 0.5% MeOH/CH2Cl2) to give a 59% yield of the desired material as a yellow foam, homogeneous by TLC in 2% MeOH/CH2Cl2, mass spectrum (FAB) m/e 723 (M+1)+.

1. customchromatographed on silica gel (124 mL for 0.467 mmole, eluted with 0.5% MeOH/CH2Cl2)