HCID 53745212, compound → HCID 54085657, compound

Participants

Reaction Steps

1.1 g of 5-(3-benzyloxy-4-methoxyphenyl)-7-[3-(2-chloro-1-ethoxy)phenyl]-4-aminopyrrolo-[2,3-d]pyrimidine and 0.3 g of sodium imidazole are heated to 85° C. in 30 ml of DMF and the mixture is stirred for 8 h. It is then cooled to RT and concentrated. After chromatography on silica gel, 5-(3-benzyloxy-4-methoxyphenyl)-7-[3-(2-(1-imidazolyl)ethoxy)phenyl]-4-amino-pyrrolo[2,3-d]pyrimidine having an m.p. of 150° C. is obtained.

Provenance & Evidence