HCID 53745212, compound → HCID 54085657, compound

HRID 362320Notes

Reaction equation

HRID 362320 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:17]2[C:25]3[C:24]([NH2:26])=[N:23][CH:22]=[N:21][C:20]=3[N:19]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH2:34][CH2:35]Cl)[CH:28]=3)[CH:18]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:37]1[CH:41]=[CH:40][N:39]=[CH:38]1.[Na]>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:17]2[C:25]3[C:24]([NH2:26])=[N:23][CH:22]=[N:21][C:20]=3[N:19]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH2:34][CH2:35][N:37]4[CH:41]=[CH:40][N:39]=[CH:38]4)[CH:28]=3)[CH:18]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 53745212HCID 53745212, compoundHCID 57373095Imidazole sodium

Product 1

HCID 54085657HCID 54085657, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.1 g of 5-(3-benzyloxy-4-methoxyphenyl)-7-[3-(2-chloro-1-ethoxy)phenyl]-4-aminopyrrolo-[2,3-d]pyrimidine and 0.3 g of sodium imidazole are heated to 85° C. in 30 ml of DMF and the mixture is stirred for 8 h. It is then cooled to RT and concentrated. After chromatography on silica gel, 5-(3-benzyloxy-4-methoxyphenyl)-7-[3-(2-(1-imidazolyl)ethoxy)phenyl]-4-amino-pyrrolo[2,3-d]pyrimidine having an m.p. of 150° C. is obtained.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-54dec01778b74b1e8b63b23821e28e60
Source dataset
uspto-grants-1999_02
Patent number
US05869485

Reaction notes

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