Phthalimide → HCID 22942366, compound

HRID 362466Notes

Reaction equation

HRID 362466 reaction equation
[C:1]1(=O)C2C(=CC=CC=2)C(=O)N1.[O:12]=[C:13]([N:26]1[CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27]1)[CH2:14][C@H:15]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:16]([OH:18])=[O:17].O=C(N1CC2C(=CC=CC=2)C1)C[C@@H](CC1C=CC=CC=1)C(O)=O.O=C(N1CC2C(=CC=CC=2)C1)CC(CC1C=CC=CC=1)C(O)=O>>[CH3:1][C:30]1[CH:29]=[C:28]2[C:33](=[CH:32][CH:31]=1)[CH2:34][N:26]([C:13](=[O:12])[CH2:14][C@H:15]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:16]([OH:18])=[O:17])[CH2:27]2

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 9883125HCID 9883125, compoundHCID 22942361HCID 22942361, compoundHCID 74011441HCID 74011441, compound

Product 1

HCID 22942366HCID 22942366, compound

Procedure

By reproducing this example using as starting material 1H-isoindole-1,3-(2H)-dione, it was possible to prepare γ-oxo-α(S)-(phenylmethyl)-2,3-dihydro-1H-isoindole-2-butanoic acid, γ-oxo-α(R)-(phenylmethyl)-2,3-dihydro-1H-isoindole-2-butanoic acid and γ-oxo-α(R,S)-(phenylmethyl)-2,3-dihydro-1H-isoindole-2-butanoic acid.

Sources & evidence

ORD record
ord-cf90f9f2dd8545d8a9cb07d975d59b8b
Source dataset
uspto-grants-1999_02
Patent number
US05869518

Reaction notes

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