Hydrochloric Acid → HCID 18314760, compound

5.3 g (26 mmol) of 8 were dissolved in 50 ml of tetrahydrofuran/methanol (2:1), 1.5 g of sodium borohydride were added at 0° C. with magnetic stirring, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was poured onto ice, conc. HCl was added to pH 1, and the mixture was extracted a number of times with diethyl ether. The combined organic phases were washed with saturated aqueous NaHCO3 solution and NaCl solution and dried (MgSO4). The solvent was removed in vacuo, and the crude product, without further purification, was taken up in 300 ml of toluene, 0.1 g of p-TsOH was added, and the mixture was refluxed for 1 hour. The reaction mixture was washed with 100 ml of saturated aqueous NaHCO3 solution, and the solvent was removed in vacuo. The crude product was purified by filtration through 200 g of silica gel (hexane), giving 4.8 g (99%) of 9 as a colorless oil.

1. additionwas added to pH 1
2. extractionthe mixture was extracted a number of times with diethyl ether
3. washThe combined organic phases were washed with saturated aqueous NaHCO3 solution and NaCl solution
4. dry with materialdried (MgSO4)
5. customThe solvent was removed in vacuo
6. customthe crude product, without further purification
7. addition0.1 g of p-TsOH was added
8. temperaturethe mixture was refluxed for 1 hour
9. washThe reaction mixture was washed with 100 ml of saturated aqueous NaHCO3 solution
10. customthe solvent was removed in vacuo
11. filtrationThe crude product was purified by filtration through 200 g of silica gel (hexane)

ORD record

ord-ddacaf011bfe4289ad26683f9c3ef0a0

Source dataset

uspto-grants-1999_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05869584