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HRID362624

反应详情

EQUATION

反应方程式

HRID 362624 的结构方程式

REACTANTS

反应物

2
结构：OO
HCID784

Hydrogen peroxide

H2O2

结构：COc1ccc2c3c1O[C@H]1C(=O)C=C[C@H]4[C@@H](C2)N(C)CC[C@]314
HCID5459910

Codeinone

C18H19NO3

PRODUCTS

生成物

1
结构：COc1ccc2c3c1OC1C(=O)C=C[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
HCID5359420

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In the first method of this invention, codeinone is reacted with hydrogen peroxide in water in the presence of an acid at about 15° to about 70° C. for a period of time depending on the scale of the reaction to afford 14-hydroxycodeinone in good yield. 14-Hydroxycodeinone so produced is hydrogenated in the same reaction media with a catalyst to afford oxycodone in good yield. Preferably the temperature is between about 40° to about 50° C. and the acid is formic acid.

WORKUP

后处理

  1. customdepending on the scale of the reaction