反应详情

温度

162 °C

15 g of palladium on carbon at 5% by weight and containing 50% of water were added to a solution of 25 g of 4-oxo-4,5,6,7-tetrahydro-1-N-(β-hydroxyethyl)indole, obtained in the preceding stage, in 300 cm3 of diglyme. The temperature of the mixture was raised and maintained at 162° C. for 10 hours. The mixture was then allowed to return to a temperature of 40° C. and then the catalyst was filtered off. The solvents were then removed under vacuum until 21.4 g of crude product were obtained which were taken up in a mixture of 30 cm3 of dichloromethane and 200 cm3 of petroleum ether. The crystals obtained were drained, washed with petroleum ether and then dried under vacuum over phosphorus pentoxide. 11 g of 4-hydroxy-1-N-(β-hydroxyethyl)indole were obtained whose elemental analysis, calculated for C10H11NO2, was:

1. temperatureThe temperature of the mixture was raised
2. customto return to a temperature of 40° C.
3. filtrationthe catalyst was filtered off
4. customThe solvents were then removed under vacuum until 21.4 g of crude product
5. customwere obtained which
6. customThe crystals obtained
7. washwashed with petroleum ether
8. dry with materialdried under vacuum over phosphorus pentoxide