Water → N-[2-(Dodecanoylamino)ethyl]-N-(2-hydroxyethyl)glycine

Participants

Reaction Conditions

Reaction Steps

A solution of N-(2-hydroxyethyl)laurylimidazoline (5 g, 18.7 mmol) and sodium hydroxide pellets (40 mg) in water (1.06 g) is heated at 80° C. for 1 hour. A mixture of glyoxal at a concentration of 40% in water (2.7 g, 18.7 mmol) and 1-propanol (5 g) is then added and the residual solution is heated for 6 hours at 80° C. An assay by capillary electrophoresis indicates a yield of 85% of N-lauroyl-N'-(2-hydroxyethyl)-N'-(carboxymethyl)ethylene-diamine.

Provenance & Evidence