Water → N-[2-(Dodecanoylamino)ethyl]-N-(2-hydroxyethyl)glycine
Reaction equation
OCC[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][N:18]=[CH:17]1.[OH-:21].[Na+].[CH:23]([CH:25]=[O:26])=O.[CH2:27]([OH:30])CC.[OH2:31]>>[C:15]([NH:16][CH2:20][CH2:19][N:18]([CH2:17][CH2:27][OH:30])[CH2:23][C:25]([OH:26])=[O:31])(=[O:21])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH3:4]Participants
6
Conditions
- Temperature
- 80 °C
Procedure
A solution of N-(2-hydroxyethyl)laurylimidazoline (5 g, 18.7 mmol) and sodium hydroxide pellets (40 mg) in water (1.06 g) is heated at 80° C. for 1 hour. A mixture of glyoxal at a concentration of 40% in water (2.7 g, 18.7 mmol) and 1-propanol (5 g) is then added and the residual solution is heated for 6 hours at 80° C. An assay by capillary electrophoresis indicates a yield of 85% of N-lauroyl-N'-(2-hydroxyethyl)-N'-(carboxymethyl)ethylene-diamine.
Sources & evidence
- ORD record
- ord-e9c520795e5946fab7f06b26b06b3522
- Source dataset
- uspto-grants-1999_02
- Patent number
- US05869712
Reaction notes
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