Acetamidomalonic acid diethyl ester → HCID 11289610, compound

HRID 362695Notes

Reaction equation

HRID 362695 reaction equation
[Na].[C:2]([NH:5][CH:6]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:4])[CH3:3].[CH:17](=[O:22])/[CH:18]=[CH:19]/[CH2:20][CH3:21]>CCO>[C:2]([N:5]1[CH:17]([OH:22])[CH2:18][CH:19]([CH2:20][CH3:21])[C:6]1([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:4])[CH3:3]

Participants

5

Reactant 3

HCID 14041Acetamidomalonic acid diethyl esterHCID 5360545SodiumHCID 5364752(E)-2-Pentenal

Product 1

HCID 11289610HCID 11289610, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

Sodium (4.02 g, 0.175 mol) was dissolved in a stirred solution of diethyl acetamidomalonate (235.4 g, 1.19 mol) in abs EtOH (1.4 L) at ambient temperature under argon. The reaction mixture was cooled to 0° C., and trans-2-pentenal (100 g, 1.08 mol) was added dropwise maintaining the reaction temperature at <5° C. After the addition, the reaction was allowed to warm to room temperature, stirred for 4 h, then quenched with acetic acid (28 mL). The solution was concentrated in vacuo, and the residue dissolved in EtOAc (1.5 L), washed with 10% NaHCO3 solution (2×300 mL), brine, and dried (MgSO4). The solution was filtered and concentrated to 700 mL, then heated to reflux and treated with hexane (1 L). On cooling, the title compound precipitated and was collected, mp 106°-109° C. 1H NMR (CD3OD) δ 5.65 (d, 1H, J=5 Hz), 4.1-4.25 (m, 4H), 2.7-2.8 (m, 1H), 2.21 (s, 3H), 2.10 (dd, 1H, J=6, 13, Hz),1.86-1.97 (m, 2H), 1.27 (t, 3H, J=7 Hz), 1.23 (t, 3H, J=7 Hz), 1.1-1.25 (m, 1H), 0.97 (t, 3H, J=7 Hz).

Workup

  1. temperaturemaintaining the reaction temperature at <5° C
  2. additionAfter the addition
  3. temperatureto warm to room temperature
  4. customquenched with acetic acid (28 mL)
  5. concentrationThe solution was concentrated in vacuo
  6. dissolutionthe residue dissolved in EtOAc (1.5 L)
  7. washwashed with 10% NaHCO3 solution (2×300 mL), brine
  8. dry with materialdried (MgSO4)
  9. filtrationThe solution was filtered
  10. concentrationconcentrated to 700 mL
  11. temperatureheated
  12. temperatureto reflux
  13. additiontreated with hexane (1 L)
  14. temperatureOn cooling
  15. customthe title compound precipitated
  16. customwas collected

Sources & evidence

ORD record
ord-4d6a8eda5fd143bb9b95ff417511351a
Source dataset
uspto-grants-1999_02
Patent number
US05869682

Reaction notes

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