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Sodium (4.02 g, 0.175 mol) was dissolved in a stirred solution of diethyl acetamidomalonate (235.4 g, 1.19 mol) in abs EtOH (1.4 L) at ambient temperature under argon. The reaction mixture was cooled to 0° C., and trans-2-pentenal (100 g, 1.08 mol) was added dropwise maintaining the reaction temperature at <5° C. After the addition, the reaction was allowed to warm to room temperature, stirred for 4 h, then quenched with acetic acid (28 mL). The solution was concentrated in vacuo, and the residue dissolved in EtOAc (1.5 L), washed with 10% NaHCO3 solution (2×300 mL), brine, and dried (MgSO4). The solution was filtered and concentrated to 700 mL, then heated to reflux and treated with hexane (1 L). On cooling, the title compound precipitated and was collected, mp 106°-109° C. 1H NMR (CD3OD) δ 5.65 (d, 1H, J=5 Hz), 4.1-4.25 (m, 4H), 2.7-2.8 (m, 1H), 2.21 (s, 3H), 2.10 (dd, 1H, J=6, 13, Hz),1.86-1.97 (m, 2H), 1.27 (t, 3H, J=7 Hz), 1.23 (t, 3H, J=7 Hz), 1.1-1.25 (m, 1H), 0.97 (t, 3H, J=7 Hz).

1. temperaturemaintaining the reaction temperature at <5° C
2. additionAfter the addition
3. temperatureto warm to room temperature
4. customquenched with acetic acid (28 mL)
5. concentrationThe solution was concentrated in vacuo
6. dissolutionthe residue dissolved in EtOAc (1.5 L)
7. washwashed with 10% NaHCO3 solution (2×300 mL), brine
8. dry with materialdried (MgSO4)
9. filtrationThe solution was filtered
10. concentrationconcentrated to 700 mL
11. temperatureheated
12. temperatureto reflux
13. additiontreated with hexane (1 L)
14. temperatureOn cooling
15. customthe title compound precipitated
16. customwas collected