HRID36280

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69018

Propionyl bromide

C3H5BrO

结构：CCCCc1nn(-c2cc(N)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1

HCID10100136

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1

HCID11764909

未命名化合物

收率 67%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

Reaction of 2-[5-amino-2-(trifluoromethyl)phenyl]-5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step D) with propionyl bromide (2 equivalents) in the presence of DMAP (1 equiv) according to the procedure of Example 69 gave a 67% yield of the title compound; homogeneous by TLC in 95:5 CH2Cl2 --MeOH.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-da1a978efe344971be44d2fe3a8cfb27
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05411980
来源说明: uspto-grants-1995_05

反应 SMILES

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:39]([F:42])([F:41])[F:40])=[C:6]([N:8]2[C:12](=[O:13])[N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[S:27](=[O:34])(=[O:33])[NH:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:17][CH:16]=3)[C:10]([CH2:35][CH2:36][CH2:37][CH3:38])=[N:9]2)[CH:7]=1.[C:43](Br)(=[O:46])[CH2:44][CH3:45]>CN(C1C=CN=CC=1)C>[CH2:35]([C:10]1[N:11]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S:27](=[O:33])(=[O:34])[NH:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[CH:19][CH:20]=2)[C:12](=[O:13])[N:8]([C:6]2[CH:7]=[C:2]([NH:1][C:43](=[O:46])[CH2:44][CH3:45])[CH:3]=[CH:4][C:5]=2[C:39]([F:41])([F:40])[F:42])[N:9]=1)[CH2:36][CH2:37][CH3:38]