Oxalyl chloride → HCID 86753732, compound

HRID 362847Notes

Reaction equation

HRID 362847 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][CH2:14]/[C:15]/2=C\C(O)=O)=[CH:10][CH:9]=1>C1(C)C=CC=CC=1>[F:7][C:8]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][CH2:14]/[C:15]/2=[CH:1]\[C:2]([Cl:4])=[O:3])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 70133496HCID 70133496, compound

Product 1

HCID 86753732HCID 86753732, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
25 °C

Procedure

Oxalyl chloride (3 ml, 0.034 mol, Aldrich) was added to a suspension of (E)-2-(7-fluoro-1,2,3,4-tetrahydro-1-naphthylidene)acetic acid (2.03 g, 0.01 mol) in toluene (35 ml) at 0° C. while protected from moisture by a nitrogen atmosphere. The stirring mixture was allowed to warm to 25° C. and was stirred for 1.5 h. Concentration in vacuo gave (E)-2-(7-fluoro-1,2,3,4-tetrahydro-1-naphthylidene)acetyl chloride which was dissolved in dichloromethane and used without purification.

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-159863fb34bb4ee38e8ee8af6e03d1eb
Source dataset
uspto-grants-1999_02
Patent number
US05872118

Reaction notes

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