Oxalyl chloride → HCID 23293646, compound

HRID 362869Notes

Reaction equation

HRID 362869 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:16]=[C:15]2[C:11]([C:12](=[O:21])[CH2:13][CH:14]2CC(O)=O)=[CH:10][CH:9]=1>ClCCl>[F:7][C:8]1[CH:16]=[C:15]2[C:11]([C:12](=[O:21])[CH2:13][CH:14]2[CH2:1][C:2]([Cl:4])=[O:3])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 23293583HCID 23293583, compound

Product 1

HCID 23293646HCID 23293646, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (4.5 g, 0.035 mol, Aldrich) was added to an ice cold stirring mixture of 2-(6-fluoro-3-oxo-1-indanyl)acetic acid (5.0 g, 0.024 mol) in dichloromethane (200 ml) under a nitrogen atmosphere. The mixture was allowed to warm to room temperature and stirring was continued for 48 hrs. The volatiles were removed from the solution by spin evaporation in vacuo with the addition of dichloromethane (3×50 ml) to give 2-(6-fluoro-3-oxo-1-indanyl)acetyl chloride which was used without purification or analysis.

Workup

  1. stirringstirring
  2. customThe volatiles were removed from the solution by spin evaporation in vacuo with the addition of dichloromethane (3×50 ml)

Sources & evidence

ORD record
ord-4aa287efb2d14d5091ed12e09e89dae8
Source dataset
uspto-grants-1999_02
Patent number
US05872118

Reaction notes

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