Ethyl 4-piperidinecarboxylate → (1-Benzhydrylpiperidin-4-yl)methanol

HRID 362885Notes

Reaction equation

HRID 362885 reaction equation
[C:1]1([CH:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:8]2[CH2:13][CH2:12][CH:11]([C:14](N)=[O:15])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1CCC(C(OCC)=O)CC1.C1(C(C2C=CC=CC=2)N2CCC(C(OCC)=O)CC2)C=CC=CC=1>>[C:1]1([CH:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:8]2[CH2:13][CH2:12][CH:11]([CH2:14][OH:15])[CH2:10][CH2:9]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 70770Ethyl 4-piperidinecarboxylateHCID 6424579Ethyl 1-(diphenylmethyl)piperidine-4-carboxylateHCID 540281161-Diphenylmethylpiperidine-4-carboxamide

Product 1

HCID 21993744(1-Benzhydrylpiperidin-4-yl)methanol

Procedure

Step 1): In a similar manner to that of Preparation 1, but replacing isonipecotamide and 1-diphenylmethylpiperidine-4-carboxamide with ethyl isonipecotate and ethyl 1-diphenylmethyl-4-piperidinecarboxylate respectively, 1-diphenylmethyl-4-hydroxymethylpiperidine was prepared.

Workup

  1. customStep 1): In a similar manner to that of Preparation 1

Sources & evidence

ORD record
ord-595c4585ea38457bafe7a2db599a8611
Source dataset
uspto-grants-1999_02
Patent number
US05872115

Reaction notes

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