Hydrochloric Acid → 4-(2-Methyl-1-phenylpropoxy)benzoic acid

Participants

Reaction Conditions

Reaction Steps

To 13-5 (8.89 g, 29.8 mmol) was added 2N potassium hydroxide (100 ml) and ethanol (50 ml). The mixture was stirred at 100° C. overnight. The ethanol was removed in vacuo and the aqueous solution was cooled in ice and acidified with 6N HCl (35 ml, 0.21 mol). The acid was extracted into ethyl acetate (50 ml) and the extract was washed with water, dried, filtered and concentrated in vacuo to obtain the oil 13-6, which solidified. The white solid melted at 125°-129° C.

Provenance & Evidence