Hydrochloric Acid → HCID 53675287, compound

HRID 363024Notes

Reaction equation

HRID 363024 reaction equation
[CH3:1][CH:2]([CH3:22])[CH:3]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[O:4][C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][CH:6]=1.[OH-].[K+].Cl>C(O)C>[CH3:1][CH:2]([CH3:22])[CH:3]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[O:4][C:5]1[CH:15]=[CH:14][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 54571989HCID 54571989, compound

Product 1

HCID 53675287HCID 53675287, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

To 13-5 (8.89 g, 29.8 mmol) was added 2N potassium hydroxide (100 ml) and ethanol (50 ml). The mixture was stirred at 100° C. overnight. The ethanol was removed in vacuo and the aqueous solution was cooled in ice and acidified with 6N HCl (35 ml, 0.21 mol). The acid was extracted into ethyl acetate (50 ml) and the extract was washed with water, dried, filtered and concentrated in vacuo to obtain the oil 13-6, which solidified. The white solid melted at 125°-129° C.

Workup

  1. customThe ethanol was removed in vacuo
  2. temperaturethe aqueous solution was cooled in ice
  3. extractionThe acid was extracted into ethyl acetate (50 ml)
  4. washthe extract was washed with water
  5. customdried
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-11d3e614db624b9fbe49d844dfdcf7c6
Source dataset
uspto-grants-1999_02
Patent number
US05872138

Reaction notes

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