4-Aminopyridine → HCID 54486187, compound

HRID 363027Notes

Reaction equation

HRID 363027 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[C:8]1([CH2:14][CH:15]([O:23][C:24]2[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([CH2:14][CH:15]([O:23][C:24]2[CH:25]=[CH:26][C:27]([C:28]([NH:1][C:2]3[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=3)=[O:29])=[CH:31][CH:32]=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 17274-AminopyridineHCID 54323174HCID 54323174, compound

Product 1

HCID 54486187HCID 54486187, compound

Procedure

4-Aminopyridine 17-7 (0.471 g, 5 mmol) was acylated with 17-6 (1.75 g, 5 mmol) using the conditions of Example 13. The amide 17-8 was obtained as a solid foam.

Sources & evidence

ORD record
ord-3c58a1df55ae407abd626f70885e3c09
Source dataset
uspto-grants-1999_02
Patent number
US05872138

Reaction notes

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