反应详情

温度

50 °C

To a solution of 22-4 (915 mg, 5.0 mmol) in 10 mL of DMF was added 1.78 g (5.50 mmol) of Cs2CO3 followed by 0.68 mL (4.9 mmol) of bromomethyl cyclohexane. The resulting solution was then heated at 50° C. for 24 h. The solvent was distilled under reduced pressure and the residue was taken up in 20 mL of EtOAc. The organic phase was extracted with 1N NaOH (2×50 mL), water (5×5 mL) and brine (5 mL), dried (MgSO4) and concentrated to afford 22-5 as an oil.

1. distillationThe solvent was distilled under reduced pressure
2. extractionThe organic phase was extracted with 1N NaOH (2×50 mL), water (5×5 mL) and brine (5 mL)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated