HCID 53847754, compound → HCID 53646796, compound

HRID 363044Notes

Reaction equation

HRID 363044 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][C:10]=2[CH:19]=[CH2:20])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CCOC(C)=O.[Pd]>[CH:1]1([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][C:10]=2[CH2:19][CH3:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 53847754HCID 53847754, compound

Product 1

HCID 53646796HCID 53646796, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To 23-4 (560 mg, 2.0 mmol) in 15 mL of EtOAc was added 56 mg of 10% Pd on carbon and the whole was hydrogenated at atmospheric pressure for 24 h. Hydrogen was removed from the reaction mixture and the solution was filtered through Celite. Evaporation of the solvent afforded 23-5 as a white solid.

Workup

  1. customHydrogen was removed from the reaction mixture
  2. filtrationthe solution was filtered through Celite
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-69d2c1db42144aaa9f95d4f946a69fc3
Source dataset
uspto-grants-1999_02
Patent number
US05872138

Reaction notes

Loading…