Water → 5-phenylpyridine-2-carboxylic Acid

HRID 363187Notes

Reaction equation

HRID 363187 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Mn]([O-])(=O)(=O)=[O:15].[K+].[OH2:20]>>[C:1]1([C:7]2[CH:8]=[N:9][C:10]([C:13]([OH:15])=[O:20])=[CH:11][CH:12]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 962WaterHCID 767442-Methyl-5-phenylpyridineHCID 516875Potassium Permanganate

Product 1

HCID 27628705-phenylpyridine-2-carboxylic Acid

Procedure

A suspension of 3-phenyl-6-methyl pyridine (1.99 g, 11.78 mmol) and potassium permanganate (7.65, 48.6 mmol), in water (50 mL) was heated at reflux for 16 hours. The reaction was allowed to cool to ambient temperature and filtered through celite to remove the solids. Acetic acid (2 mL) was added to the colourless filtrate and the product was collected as a white solid by filtration.

Workup

  1. temperatureat reflux for 16 hours
  2. filtrationfiltered through celite
  3. customto remove the solids
  4. additionAcetic acid (2 mL) was added to the colourless filtrate
  5. filtrationthe product was collected as a white solid by filtration

Sources & evidence

ORD record
ord-343691b2d04c48aca1c08a10cca1ee35
Source dataset
uspto-grants-1999_02
Patent number
US05872136

Reaction notes

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