反应详情

To a solution of 2-(3-trifluoromethoxyphenyl)-5-carboxy pyridine (2.0 g, 7.06 mmol) in tetrahydrofuran (15 mL) at 0° C. was added 1.0M lithium aluminum hydride in tetrahydrofuran (7.07 mL, 7.07 mmol) over 10 minutes. The reaction was allowed to stir at ambient temperature for 4 hours, cooled to 0° C., and quenched by dropwise addition of saturated Na2SO4 (1.0 mL). The reaction was diluted with diethylether, filtered through a pad of Celite and the filtrate evaporated in vacuo. The residue was chromatographed (silica gel, 50% EtOAc in hexanes) to afford the title compound.

1. temperaturecooled to 0° C.
2. customquenched by dropwise addition of saturated Na2SO4 (1.0 mL)
3. additionThe reaction was diluted with diethylether
4. filtrationfiltered through a pad of Celite
5. customthe filtrate evaporated in vacuo
6. customThe residue was chromatographed (silica gel, 50% EtOAc in hexanes)