Dimethylformamide → 2-(2-Dimethylaminoethen-2-yl)-3-nitro-6-methoxypyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.0 gm (11.9 mMol) 6-methoxy-3-nitro-2-picoline and 16 mL (119 mMol) dimethylformamide dimethylacetal in 20 mL dimethylformamide was heated at 100° C. for 7 hours. The reaction mixture was concentrated under reduced pressure. The residue was treated with toluene and concentrated under reduced pressure. The residual solid was dried at 50° C. under reduced pressure for 1 hour to provide 2.70 gm (100%) of the desired compound as a red solid.

Provenance & Evidence