反应详情

温度

100 °C

A mixture of 2.0 gm (11.9 mMol) 6-methoxy-3-nitro-2-picoline and 16 mL (119 mMol) dimethylformamide dimethylacetal in 20 mL dimethylformamide was heated at 100° C. for 7 hours. The reaction mixture was concentrated under reduced pressure. The residue was treated with toluene and concentrated under reduced pressure. The residual solid was dried at 50° C. under reduced pressure for 1 hour to provide 2.70 gm (100%) of the desired compound as a red solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionThe residue was treated with toluene
3. concentrationconcentrated under reduced pressure
4. customThe residual solid was dried at 50° C. under reduced pressure for 1 hour