反应详情

Potassium hydroxide (10% in methanol, 15 ml, 26.8 mmol), 1H-indole (1.5 g, 13 mmol), and 7-indolizinone (1.39 g, 10 mmol) were combined and heated to reflux for 15 hours. The mixture was diluted with water and the precipitate was filtered. The brown filter cake was triturated with hot methanol, cooled to room temperature, and the solid collected to give 1.99 g of desired product. (84%).

1. temperatureheated
2. temperatureto reflux for 15 hours
3. filtrationthe precipitate was filtered
4. customThe brown filter cake was triturated with hot methanol
5. customthe solid collected