5-Chloroindole → HCID 9903606, compound

HRID 363329Notes

Reaction equation

HRID 363329 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH:11]1[C:19]2[N:14]([CH:15]=[CH:16][C:17](=O)[CH:18]=2)[CH2:13][CH:12]=1>>[CH2:11]1[CH:19]2[N:14]([CH2:15][CH:16]=[C:17]([C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=4)[NH:7][CH:6]=3)[CH2:18]2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 871105-ChloroindoleHCID 69592000HCID 69592000, compound

Product 1

HCID 9903606HCID 9903606, compound

Procedure

The 5-chloro-1H-indole (1.00 g, 6.63 mmol) and 7-indolizinone (1.39 g, 9.95 mmol) were converted to product by the procedure of Example 2 to give 595 mg. (33.1%).

Workup

  1. customto give 595 mg

Sources & evidence

ORD record
ord-03671aab999747e7ad50263f6c94edb1
Source dataset
uspto-grants-1999_02
Patent number
US05874427

Reaction notes

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