反应详情

Hydrazine hydrate (2.4 ml, 50 mmol) was added to a solution of 2,6-bis-(phthalimidomethyl)-pyridine (1.99 g, 5.0 mmol) in 95% ethanol (50 ml). The mixture was refluxed for 3 hours. After cooling it was concentrated on a rotary evaporator and the residue was purified by chromatography on silica gel (eluent: methylene chloride/ethanol, 100/2) to give 2,6-bis-(aminomethyl)-pyridine in the form of a yellow oil.

1. temperatureThe mixture was refluxed for 3 hours
2. temperatureAfter cooling it
3. concentrationwas concentrated on a rotary evaporator
4. customthe residue was purified by chromatography on silica gel (eluent: methylene chloride/ethanol, 100/2)