Hydrogen Bromide → 1,3-Di-n-butyl-8-bromo Xanthine

HRID 3634Notes

Reaction equation

[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([N+]([O-])=O)=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].[BrH:23]>>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([Br:23])=[N:10][C:9]=2[N:8]([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 99444751,3-Di-n-butyl-8-nitro Xanthine

Product 1

HCID 101544891,3-Di-n-butyl-8-bromo Xanthine

Procedure

1,3-Di-n-butyl-8-bromo xanthine was prepared from 1,3-di-n-butyl-8-nitro xanthine (0.5 g, 0.0016 mol) and concentrated hydrobromic acid (8 ml) using the procedure as described in Example 15. The title product was obtained after recrystallisation from ethanol, yield 0.4 g (91%), m.pt. 178° C.

Sources & evidence

ORD record: ord-38d4d17186b6440b9a7304522d7693ad
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05734051

Reaction notes

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