反应详情

E-(3-{4-[1-(4-{2-[4-(3-Dipropylaminopropoxy)phenyl]benzoimidazol-1-yl}but-2-enyl)-1H-benzoimidazol-2-yl]phenoxy}propyl)dipropylamine (Example 2) (100 mg) is hydrogenated at 50 pounds per square inch (psi) in methanol (20 mL) with 20% palladium on carbon (10 mg) for 6 hours. The mixture is filtered and evaporated to leave a yellow solid. The solid is purified by MPLC on silica gel eluting with 200:8:1 dichloromethane:ethanol:0.880 aqueous ammonia to give 49 mg of the title compound as a white solid; mp 141°-143° C.

1. filtrationThe mixture is filtered
2. customevaporated
3. customto leave a yellow solid
4. customThe solid is purified by MPLC on silica gel eluting with 200:8:1 dichloromethane