E-(3-{4-[1-(4-{2-[4-(3-Dipropylaminopropoxy)phenyl]benzoimidazol-1-yl}but-2-enyl)-1H-benzoimidazol-2-yl]phenoxy}propyl)dipropylamine → (3-{4-[1-(4-{2-[4-(3-Dipropylaminopropoxy)phenyl]benzoimidazol-1-yl}butyl)-1H-benzoimidazol-2-yl]phenoxy}propyl)dipropylamine

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Reaction Steps

E-(3-{4-[1-(4-{2-[4-(3-Dipropylaminopropoxy)phenyl]benzoimidazol-1-yl}but-2-enyl)-1H-benzoimidazol-2-yl]phenoxy}propyl)dipropylamine (Example 2) (100 mg) is hydrogenated at 50 pounds per square inch (psi) in methanol (20 mL) with 20% palladium on carbon (10 mg) for 6 hours. The mixture is filtered and evaporated to leave a yellow solid. The solid is purified by MPLC on silica gel eluting with 200:8:1 dichloromethane:ethanol:0.880 aqueous ammonia to give 49 mg of the title compound as a white solid; mp 141°-143° C.

Provenance & Evidence