p-Toluenesulfonic acid → 4-Methylbenzene-1-sulfonic acid--5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one (1/1)

HRID 363720Notes

Reaction equation

HRID 363720 reaction equation
[SiH3][O:2][C:3]1[S:11][C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[CH:4]=1.[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([S:19]([OH:22])(=[O:21])=[O:20])=[CH:17][CH:18]=1>>[S:11]1[CH:10]2[C:5]([CH2:6][NH:7][CH2:8][CH2:9]2)=[CH:4][C:3]1=[O:2].[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([OH:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 131070403HCID 131070403, compound

Product 1

HCID 451083204-Methylbenzene-1-sulfonic acid--5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one (1/1)

Procedure

In the following, Reaction 2 and Reaction 3 are explained by Examples 5 to 17. In this case, yield means yield of 5-alkyl-2-silyloxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (mole) or 2-silyloxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (mole) based on 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]-pyridin-2one.p-toluenesulfonate (mole).

Workup

  1. customIn the following, Reaction 2 and Reaction 3
  2. customIn this case, yield

Sources & evidence

ORD record
ord-c5d8175e02e0498283dea0b54674f289
Source dataset
uspto-grants-1999_02
Patent number
US05874581

Reaction notes

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