Hydrochloric Acid → 2-(Pyridin-2-yl)quinoline-4-carboxylic acid

HRID 363732Notes

Reaction equation

HRID 363732 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1(C([O-])=O)[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8]1.[Na+].Cl>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70240266Sodium 2-(2-pyridinyl)-4-carboxyquinoline carboxylate

Product 1

HCID 241032-(Pyridin-2-yl)quinoline-4-carboxylic acid

Procedure

The free acid is prepared by neutralizing an aqueous solution of the sodium 2-(2-pyridyl)-4-carboxyquinoline carboxylate 3 with 10% HCl. The acid is somewhat soluble in acidic solution, and care should be taken not to overacidify; a pH of 7 is optimum. The solid is filtered, washed with 40 mL of acetone and allowed to air dry.

Workup

  1. customThe free acid is prepared
  2. filtrationThe solid is filtered
  3. washwashed with 40 mL of acetone
  4. customto air dry

Sources & evidence

ORD record
ord-6555d9c071b74344aab1a666d2ab3e89
Source dataset
uspto-grants-1999_02
Patent number
US05874587

Reaction notes

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