Hydrochloric Acid → HCID 66756432, compound

HRID 363873Notes

Reaction equation

HRID 363873 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:26])[CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[NH:10][CH2:9][C@H:8]([NH:17]C(OC(C)(C)C)=O)[C:7]1=[O:25]>C(Cl)Cl>[ClH:1].[CH3:2][O:3][C:4](=[O:26])[CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[NH:10][CH2:9][C@H:8]([NH2:17])[C:7]1=[O:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

Product 1

HCID 66756432HCID 66756432, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Anhydrous HCl was bubbled into a solution of (3S)-2-oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester (600a, 4.0 g, 11.4 mmol) in 20 ml of CH2Cl2 for 20 min then stirred for 1 h at RT. The reaction was evaporated to give (3S)-2-oxo-3-amino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester hydrochloride as a white solid.

Workup

  1. customThe reaction was evaporated

Sources & evidence

ORD record
ord-d2015167d3d04ccc83835aa866855d89
Source dataset
uspto-grants-1999_02
Patent number
US05874424

Reaction notes

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