Pyrrolidine → 1,3-Di-n-butyl-8-pyrrolidinyl Xanthine

HRID 3639Notes

Reaction equation

HRID 3639 reaction equation
[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11](Br)=[N:10][C:9]=2[N:8]([CH2:17][CH2:18][CH2:19][CH3:20])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][C:11]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[N:10][C:9]=2[N:8]([CH2:17][CH2:18][CH2:19][CH3:20])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 101544891,3-Di-n-butyl-8-bromo Xanthine

Product 1

HCID 99021881,3-Di-n-butyl-8-pyrrolidinyl Xanthine

Procedure

The title compound was prepared from 1,3-di-n-butyl-8-bromo xanthine (1 g, 0.0029 ml) and pyrrolidine (0.041 g, 0.0057 mol) using an analogous procedure to that described in Example 19. The title product was obtained as a crystalline solid, m.pt. >250° C.

Sources & evidence

ORD record
ord-a4381712e0b94957ad0bd9bce274790d
Source dataset
uspto-grants-1998_03
Patent number
US05734051

Reaction notes

Loading…