反应详情

Thionyl chloride (600 ml) is added dropwise, with stirring, over a period of 2 hours, to a suspension of 3,4-dimethoxy-phenylacetic acid (549.4 g) in methylene chloride (600 ml). After the development of gas has ended (16 hours) the mixture is refluxed for a further hour. After the highly volatile components have been removed the residue is distilled in vacuo.

1. custom(16 hours)
2. temperatureis refluxed for a further hour
3. customAfter the highly volatile components have been removed the residue
4. distillationis distilled in vacuo