Formaldehyde → HCID 20240118, compound

HRID 364096Notes

Reaction equation

HRID 364096 reaction equation
[CH3:1][O:2][C:3]1[C:31]([O:32][CH3:33])=[CH:30][C:6]2[CH2:7][C:8](=[O:29])[N:9]([CH2:12][CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]3[CH:25]=[C:24]([Br:26])[C:23]([NH2:27])=[C:22]([Br:28])[CH:21]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1.C=O.[C:36]([BH3-])#N.[Na+]>>[CH3:1][O:2][C:3]1[C:31]([O:32][CH3:33])=[CH:30][C:6]2[CH2:7][C:8](=[O:29])[N:9]([CH2:12][CH2:13][CH2:14][N:15]([CH3:36])[CH2:16][CH2:17][CH2:18][NH:19][C:20]3[CH:25]=[C:24]([Br:26])[C:23]([NH2:27])=[C:22]([Br:28])[CH:21]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 13579678HCID 13579678, compound

Product 1

HCID 20240118HCID 20240118, compound

Procedure

The title compound is prepared from N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-3-(4-amino-3,5-dibromophenylamino)-propylamine, paraformaldehyde and sodium cyanoborohydride analogously to Example 5.

Sources & evidence

ORD record
ord-b2a9764a685f4999a4759668c91ef52c
Source dataset
uspto-grants-1986_08
Patent number
US04604389

Reaction notes

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