Formaldehyde → HCID 20240138, compound

HRID 364097Notes

Reaction equation

HRID 364097 reaction equation
[CH3:1][O:2][C:3]1[C:32]([O:33][CH3:34])=[CH:31][C:6]2[CH2:7][C:8](=[O:30])[N:9]([CH2:12][CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1.C=O.[C:37]([BH3-])#N.[Na+]>>[CH3:1][O:2][C:3]1[C:32]([O:33][CH3:34])=[CH:31][C:6]2[CH2:7][C:8](=[O:30])[N:9]([CH2:12][CH2:13][CH2:14][N:15]([CH3:37])[CH2:16][CH2:17][CH2:18][NH:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 13579672HCID 13579672, compound

Product 1

HCID 20240138HCID 20240138, compound

Procedure

The title compound is prepared from N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-3-(3,4-dimethoxyphenylamino)-propylamine, paraformaldehyde and sodium cyanoborohydride analogously to Example 5.

Sources & evidence

ORD record
ord-6d5d36903d6545969141bed2b634df63
Source dataset
uspto-grants-1986_08
Patent number
US04604389

Reaction notes

Loading…