Triethylamine → HCID 14330455, compound

HRID 364125Notes

Reaction equation

HRID 364125 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:10][C:11](=[CH2:15])[C:12]([OH:14])=[O:13].C(N(CC)CC)C>ClC1C=CC=CC=1Cl>[CH3:1][O:2][C:3]1[C:4]2[S:9][CH2:10][CH:11]([C:12]([OH:14])=[O:13])[CH2:15][C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 14330452HCID 14330452, compound

Product 1

HCID 14330455HCID 14330455, compound

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

A mixture 22.5 g of α-(o-methoxyphenylthiomethyl)-acrylic acid, 2.53 g of triethylamine and 200 ml of o-dichlorobenzene is heated for 12 hours at 195°. After dilution with ether the products are extracted with sodium bicarbonate solution. Acidification of the basic extracts affords 8-methoxy-3,4-dihydro-2H-[1]-benzothiopyran-3-carboxylic acid, m.p. 138°-144°.

Workup

  1. extractionAfter dilution with ether the products are extracted with sodium bicarbonate solution

Sources & evidence

ORD record
ord-0be0c90fb4ef42c4bfda64adeeb0851f
Source dataset
uspto-grants-1986_08
Patent number
US04604397

Reaction notes

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