HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 20240299, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Methoxy-2H-1-benzopyran-3(4H)-one | HCID 14006911 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 20240299 | HCID 20240299 | — |
Reaction Steps
The starting material is prepared as follows: A solution of 17.8 g of 6-methoxy-3-chromanone, 7.5 g of pyrrolidine and 0.1 ml of trifluoroacetic acid in 200 ml of toluene is refluxed for 8 hours in a Dean Stark apparatus. After removal of solvent in vacuo 14.0 g of acrylamide is added and the mixture is heated for 3 hours at 80°. Water is added, the organic layer is separated and evaporated to dryness to afford 9-methoxy-1,2,3,5-tetrahydro-4H-[1]-benzopyrano[3,4-b]pyridin-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604397 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-bcec6d3bcd044a71a75cf4d574e9cad1 |
| Source note | uspto-grants-1986_08 |