反应详情

The starting material is prepared as follows: A solution of 17.8 g of 6-methoxy-3-chromanone, 7.5 g of pyrrolidine and 0.1 ml of trifluoroacetic acid in 200 ml of toluene is refluxed for 8 hours in a Dean Stark apparatus. After removal of solvent in vacuo 14.0 g of acrylamide is added and the mixture is heated for 3 hours at 80°. Water is added, the organic layer is separated and evaporated to dryness to afford 9-methoxy-1,2,3,5-tetrahydro-4H-[1]-benzopyrano[3,4-b]pyridin-3-one.

1. customThe starting material is prepared
2. customAfter removal of solvent in vacuo 14.0 g of acrylamide
3. additionis added
4. temperaturethe mixture is heated for 3 hours at 80°
5. additionWater is added
6. customthe organic layer is separated
7. customevaporated to dryness