Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

HRID 36414Notes

Reaction equation

HRID 36414 reaction equation
[CH:1](=O)[C:2]1[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:4]([O:5][CH3:6])[CH:3]=1.[CH:13]([OH:15])=[O:14].[CH2:16](N(CC)CC)C>>[CH3:6][O:5][C:4]1[CH:3]=[C:2]([CH2:1][CH2:16][C:13]([OH:15])=[O:14])[CH:11]=[CH:10][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 8419VeratraldehydeHCID 8471Triethylamine

Product 1

HCID 750193-(3,4-Dimethoxyphenyl)propionic acid

Procedure

4.80 g (0.025 mol) of 2,2-pentamethylene-1,3-dioxane-4,6-dione (m.p.: 94° C.) and 4.15 g (0.025 mol) of veratraldehyde were added to 25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1. The reaction was carried out according to Example 1.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-d4a2ef45df514ae28f6fa2927ee423e7
Source dataset
uspto-grants-1995_05
Patent number
US05414108

Reaction notes

Loading…