反应详情

The starting material is prepared as follows: A mixture of 2.57 g of 3-bromo-6-methoxy-4-chromanone and 3.3 g of the ethylene ketal of 1-(propylamino)-2-propanone in 500 ml of toluene is refluxed for 17 hours. The resulting product is dissolved in 20 ml of nitromethane and added to 50 ml of 85% polyphosphoric acid. After 48 hours at room temperature the reaction is poured onto ice to afford 9-methoxy-4-propyl-2,3,4a,5-tetrahydro-4H-[1]-benzopyrano[3,4-b]pyridin-2-one.

1. customThe starting material is prepared
2. temperatureis refluxed for 17 hours
3. additionAfter 48 hours at room temperature the reaction is poured onto ice