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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 36417Generated: October 31, 2026

Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

https://huagongshe.com/reaction/36417

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormic AcidHCID 284—
ReactantVeratraldehydeHCID 8419—
ReactantHCID 19938681HCID 19938681—
SolventTriethylamineHCID 8471—
Product3-(3,4-Dimethoxyphenyl)propionic acidHCID 75019—

Reaction Conditions

Temperature95 °C

Reaction Steps

3.95 g (0.025 mol) of 2-methyl-2-ethyl-1,3-dioxane-4,6-dione and 4.15 g (0.025 mol) of veratraldehyde were weighed in to 25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1. The reaction mixture was heated to 95° C. during 1 hour and maintained at the same temperature for 2 hours, then Example 1 was followed.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05414108
Source datasetuspto-grants-1995_05
ORD IDord-f79d94b173f24569be97cacd157bda37
Source noteuspto-grants-1995_05