2-BROMOETHYLAMINE HYDROCHLORIDE → HCID 54585665, compound

HRID 364185Notes

Reaction equation

HRID 364185 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[N:6]=[C:5]3[C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[S:20][C:3]=1[C:4]=23.Cl.[Br:26][CH2:27][CH2:28][NH2:29]>CCO>[BrH:26].[CH2:14]([N:13]([CH2:16][CH3:17])[CH2:12][CH2:11][N:7]1[C:8]2[CH:9]=[CH:10][C:2]([NH:1][CH2:27][CH2:28][NH2:29])=[C:3]3[S:20][C:19]4[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=4[C:5]([C:4]=23)=[N:6]1)[CH3:15]

Participants

4

Reactant 2

HCID 122086202-BROMOETHYLAMINE HYDROCHLORIDEHCID 13689033HCID 13689033, compound

Product 1

HCID 54585665HCID 54585665, compoundYield 37.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5.0 g (0.015 mol) of 5-amino-N,N-diethyl-2H[1]benzothiopyrano[4,3,2-cd]indazole-2-ethanamine and 9.2 g (0.045 mol) of 2-bromoethylamine, hydrochloride in 50 ml of EtOH was heated under reflux for four days and allowed to cool to room temperature. The solid was collected and recrystallized from MeOH to give 2.6 g of product, mp 263° C. dec.

Workup

  1. temperatureunder reflux for four days
  2. customThe solid was collected
  3. customrecrystallized from MeOH

Sources & evidence

ORD record
ord-2ff49878ebf94ee5baacf63be9912c73
Source dataset
uspto-grants-1986_08
Patent number
US04604390

Reaction notes

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