Hydrogen Bromide → 1,3-Di-cyclohexylmethyl-8-bromo xanthine

HRID 3642Notes

Reaction equation

HRID 3642 reaction equation
[CH:1]1([CH2:7][N:8]2[C:17](=[O:18])[C:16]3[NH:15][C:14]([N+]([O-])=O)=[N:13][C:12]=3[N:11]([CH2:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[C:9]2=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BrH:29]>>[CH:1]1([CH2:7][N:8]2[C:17](=[O:18])[C:16]3[NH:15][C:14]([Br:29])=[N:13][C:12]=3[N:11]([CH2:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[C:9]2=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 102219271,3-Di-cyclohexylmethyl-8-nitro xanthine

Product 1

HCID 102025051,3-Di-cyclohexylmethyl-8-bromo xanthine

Procedure

The title compound was prepared from 1,3-di-cyclohexylmethyl-8-nitro xanthine (1 g, 0.0026 mol) and concentrated hydrobromic acid (40 ml, 48%) over 32 hours using an analogous procedure to that described in Example 15. The title product was obtained as a crystalline solid, m.pt. 247° C.

Sources & evidence

ORD record
ord-712a4c23c26a4619a1659f080875532d
Source dataset
uspto-grants-1998_03
Patent number
US05734051

Reaction notes

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