反应详情

温度

110 °C

A mixture of 4.61 g of 5-amino-2-[2-(diethylamino)-ethyl]-2H-benzothiopyrano[4,3,2-cd]indazol-9-ol and 4.3 g of bromoethylphthalimide is heated at 110° C. for 16 hours, then cooled to room tempaerature. The mixture is combined with 300 ml of chloroform and 10 ml of N,N-diisopropylethylamine and heated under reflux for 2 hours, then washed with three 350-ml portions of water. The solution is evaporated to afford an oily solid which is triturated with 2-propanol. The resulting solid is collected and dried to give the title compound, mp 163°-166° C.

1. temperaturecooled to room tempaerature
2. temperatureheated
3. temperatureunder reflux for 2 hours
4. washwashed with three 350-ml portions of water
5. customThe solution is evaporated
6. customto afford an oily solid which
7. customis triturated with 2-propanol
8. customThe resulting solid is collected
9. customdried