反应详情

温度

25 °C

To 3.3 g (0.022 ml) of 3,4-dihydro-phthalazin-1(2H)-one dissolved in 100 ml of xylene was added 3.9 g (0.022 mol) of N-methylisatoic anhydride and the solution was stirred and heated at reflux under N2 for 16 hours. The mixture was then cooled to room temperature (about 25° C.) whereupon a heavy precipitate formed. The 3-(o-methylaminobenzoyl)-3,4-dihydro-phthalazin-1(2H)-one was collected as a solid, washed well with xylene to give an off-white powder, mp 199°-202° C.

1. temperatureheated
2. temperatureat reflux under N2 for 16 hours
3. customformed
4. customThe 3-(o-methylaminobenzoyl)-3,4-dihydro-phthalazin-1(2H)-one was collected as a solid
5. washwashed well with xylene
6. customto give an off-white powder, mp 199°-202° C.