HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(3-aminopropylthio)pyrimidine → HCID 178503922, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(3-aminopropylthio)pyrimidine | HCID 21298711 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178503922 | HCID 178503922 | 147.5% |
Reaction Steps
A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[(3-amino)propylthio]pyrimidine (180 mg.) in acetonitrile (2 ml.) was treated with dimethyl (cyanoimidio)dithiocarbonate (85 mg.) and the solution stood at room temperature for 18 hours. The crystalline solid which precipitated was collected to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[3-(3-cyano-2-methylisothioureido)propylthio]pyrimidine (175 mg.), m.p. 189°-190°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-eae0629e53ca48ad8669cc705d33b6a5 |
| Source note | uspto-grants-1986_08 |