Methylamine → HCID 178485047, compound

HRID 364279Notes

Reaction equation

HRID 364279 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[N:22][C:23]#[N:24])SC)[N:8]=1.[CH3:28][NH2:29]>C(O)C>[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]([NH:29][CH3:28])=[N:22][C:23]#[N:24])[N:8]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178503915HCID 178503915, compound

Product 1

HCID 178485047HCID 178485047, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine (0.17 g.) in 33% w/v methylamine in ethanol was left at room temperature for 18 hours and then evaporated to dryness. The residue was triturated with ether and the insoluble solid collected and recrystallised from ethyl acetate to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(2-cyano-3-methylguanidino)butylthio]pyrimidine, m.p. 179°-180°.

Workup

  1. customevaporated to dryness
  2. customThe residue was triturated with ether
  3. customthe insoluble solid collected
  4. customrecrystallised from ethyl acetate

Sources & evidence

ORD record
ord-992247e8df0f4b40a4b37ba0175d178c
Source dataset
uspto-grants-1986_08
Patent number
US04604465

Reaction notes

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