反应详情

温度

60 °C

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

1. stirringthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
2. extractionThe mixture was extracted with methylene chloride
3. washwashed with water
4. customdried
5. customThe solvent was evaporated under reduced pressure